The IL-2:IL-2R protein-protein interaction is of central importance to both healthy and diseased immune responses, and is one of the earliest examples of successful small-molecule inhibitor discovery against this target class. Drug-like inhibitors of IL-2 have been identified through a combination of fragment discovery, structure-based design, and medicinal chemistry; this discovery approach il...

scented rose species are very important in the genus rosa due to their use in highly-prized essential oil production and as garden roses. the fragrance of the rose flower (attar) captured by extraction is one of the most valuable flavor and fragrance products. a comprehensive study of the papers published in the field of in vitro culture and biotechnology of these species, particularly damask r...

Keyphrases D Pharmaceutical salts-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Salts, pharmaceutical-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Physicochemical properties-dissolution, solubility, stability, and organoleptic properties of pharmaceutical salts,...

In the present study the efficacy of arkas (water distillate) and essential oils of cinnamon and clove is evaluated as a preservative for kwathas. Arkas and essential oils of cinnamon and clove have good preservative property without altering the physico - chemical properties of kwatha.

The current approaches to the quality control of herbal medicines are either compound-oriented or pattern-oriented, the former targeting specific components with some known chemical properties and the latter targeting all detectable components. The marker approach uses specific chemical compounds with known molecular structures, while the multi-compound approach uses both chemical compounds wit...

Organic solvents are constantly present in the pharmaceutical production processes. They are usually used at any step of the synthesis pathway during the drug product formulation process. Organic solvents play an important role in the pharmaceutical industry, and appropriate selection of the solvents for the synthesis of drug substance may enhance the yield, or determine characteristics such as...